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The PPP is one of the three main ways the body creates molecules with One of the uses of NADPH in the cell is to prevent oxidative stress

10.3389/fphar.2021.794298 64 LiuZ.YaoX.SunB.JiangW.LiaoC.DaiX.et al (2021)

Similarly, ER-mitochondria associations and VAPB-PTPIP51 interactions are disrupted by ALS-associated mutant FUS (Stoica et al., 2016), which results in increased production of ROS